MyBioSource.com's Rabbit Anti-Megalin/LRP2 Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Immunohistochemistry - fixed. The Rabbit Anti-Megalin/LRP2 Antibody was generated using LRP2 as the antigen and it reacts with Mouse.
Description
LRP2 is a member of the LDL receptor gene family, as a component of the SHH signaling machinery in the RDVM. Lipoprotein related receptor 2 (LRP2) has been shown to play a crucial role in neural tube development in mouse models. Lipoprotein-related receptor protein 2 (LRP2) is important for the development of the embryonic neural crest and brain in both mice and humans. Megalin (or LRP2) is an endocytic receptor that plays a central role in embryonic development and adult tissue homeostasis. Loss of this receptor in congenital or acquired diseases results in multiple organ dysfunctions, including forebrain malformation (holoprosencephaly) and renal reabsorption defects (renal Fanconi syndrome)